Current Developments in LC-MS for Pharmaceutical Analysis

Current developments in LC-MS for pharmaceutical analysis.

The current developments in liquid chromatography-mass spectrometry (LC-MS) and its applications to the analysis of pharmaceuticals are reviewed. Various mass spectrometric techniques, including electrospray and nanospray ionization, atmospheric pressure chemical ionization and photoionization and their interface with liquid chromatographic techniques are described. These include high performan...

Automated Sample Preparation for the Monitoring of Pharmaceutical and Illicit Drugs by LC-MS/MS

Automated sample preparation enables highly reproducible quantitative analyses while meeting the increased efficiency needs often required for sample processing in laboratories. This application note describes results obtained using a liquid handling-based automation system for the sample preparation of compounds to be analyzed by LC-MS/ MS and applied to the monitoring of multiple classes of p...

Computational Analysis of LC-MS/MS Data for Metabolite Identification

Metabolomics aims at the detection and quantitation of metabolites within a biological system. As the most direct representation of phenotypic changes, metabolomics is an important component in system biology research. Recent development on highresolution, high-accuracy mass spectrometers enables the simultaneous study of hundreds or even thousands of metabolites in one experiment. Liquid chrom...

Metabolomics: Lc-ms Analysis Development

Analysis of Opiates in Oral Fluids Utilizing LC-MS/MS

LC/MS/MS is a very selective and sensitive analytical technique for detection and quantification of analytes in complex matrices. As a result, the use of LC/MS/MS in forensic toxicological applications has been significantly increasing over the past decade. The use of oral fluid as an alternative biological matrix for drug testing has also increased. However, the sample volume is usually much s...